A sedating effect
We would like to support their findings with our experience.A few years ago one of us (PS) together with eight other anesthesiologists took part as volunteers in a clinical study of the effects of IV lidocaine on pain perception (unpublished data).The main use for niaprazine is its intense sedative effect (as opposed to its antihistamine effects).Vertigo and daytime sedation are frequently encountered with the use of this drug.We received 1 mg/kg IV lidocaine as a bolus, followed by an infusion of 5 mg/kg over 2 hr.Even though the blood lidocaine concentrations were less than that associated with toxicity (5 μg/m L) (), all subjects reported deep sedation, and muscle weakness.The side effects of clemastine are greatly dependent on the dose, and sometimes can produce contradictory responses.
Although it is a sedative antihistamine, its effects are less intense than many other drugs of this nature.
Medical professionals seek out diphenhydramine when a substantial histamine release demands a fast, effective reversal, and is therefore often the drug of choice for allergic rhinitis, motion sickness, insect bites and stings, and hives.
Profound drowsiness is a very common side effect, as is dizziness, difficulty concentrating, and urinary retention.
Doxylamine can be used by itself as a sleep aid or combined with other drugs for cold and allergy relief (usually in a night-time formula).
It is sometimes used along with Vitamin B6 to stop morning sickness during pregnancy.